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The most important source of reactive oxygen under normal conditions in aerobic organisms is probably the loss of activated oxygen from mitochondria during normal operation of oxidative respiration.Other enzymes capable of producing superoxide are xanthine oxidase, NADPH oxidase and cytochrome P450. Hydrogen peroxide is produced by a wide variety of enzymes including oxidases and monooxygenases. Reactive oxygen species play an important role in cell signaling, in a process called redox signaling. Thus, to maintain cellular homeostasis is a balance between reactive oxygen production and consumption.The best studied cellular antioxidants are the enzymes superoxide dismutase (SOD), catalase and glutathione peroxidase. Antioxidant enzyme less studied (but probably very important) are the peroxiredoxin and sulfiredoxin. Other enzymes that have antioxidant properties (although this is not its primary role) include paraoxonase, glutathione S-transferase, and aldehyde dehydrogenase.Visit http://www.oxis.com for more information on Anti aging, antioxidant, glutathione, penny stocks & free radical.

Oxidative stress contributes to tissue injury after irradiation and hyperoxia. It is suspected (though not proven) that is important in neurodegenerative diseases including Lou Gehrig’s disease, Parkinson’s disease, Alzheimer’s disease and Huntington’s disease. It is also considered to be linked to cardiovascular diseases, since the oxidation of LDL in the vascular endothelium is a precursor to plaque formation. Also plays a role in the ischemic cascade due to damage by oxygen reperfusion following hypoxia. This cascade includes both stroke and heart attacks. Follow Oxis on Twitter

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